Baldness, or androgenetic alopecia, results in the depletion of hair and hair miniturization. It is caused by genetics and hormones. In the terminal stage, there is no hair left and the patient is bald.
Androgenetic alopecia is the most common cause of alopecia in men: at least three factors are predominant: the age of the patient, heredity and the physiology of the hair. About 30% of men will be affected by this type of baldness by the age of 30, and 80% by the age of 80.
At the genetic level, many genes have been identified that are related to hair structure, development and risk of hair loss. Some of these genes are located on the X chromosome (transmitted from mother to son) and some are genes present on autosomal chromosomes, such as chromosome 20.
At the hormonal level, dihydrotestosterone (DHT), obtained through the action of the enzyme 5 alpha-reductase on testosterone, alters the balance of hair cycles. It induces an overly rapid turnover of the hair cycle, miniaturization of the hair, and progressive thinning of the hair. The capital of hair cycles is depleted and the patient gradually becomes bald.
This development is repeated by the Norwood and Hamilton classification in men, which allows the patient's stage of baldness to be assessed. This alopecia inexorably induces a more aged appearance of the face, more or less well experienced and considered by the patient. Stage 1 : Hollowing of the temporal and/or frontal gulfs. Stage 2 : More significant hollowing of the temporal and/or frontal gulfs. Beginning of receding of the frontal line. Stage 3 : Established receding of the frontal line. Deeper hollowing of the temporal and/or frontal gulfs. Beginning of tonsure (affected vertex). Stage 4 : Increase in stage 3, with extension to the intermediate zone (midscalp). Stage 5 : Confluence of the anterior and posterior alopecic zones. Stage 6 : Increase in stage 5, with posterior receding of the whirlpool zone. Stage 7 : Terminal stage. Hippocratic alopecia, only a crown of hair extending from the temples to the nape of the neck remains.
The diagnosis is often clinical. It is often confirmed by an analysis of the skin of the scalp, the hair and sometimes a blood test.
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